Each week a theme is chosen and different kinds of stories are created on that theme. The show is heard by 2.2 million listeners each week on over 500 public radio stations in the U.S., with another 3.6 million people downloading each episode as a podcast.

This American Life is usually one of the five top podcasts on iTunes and heard on radio stations in Ireland and Germany, and all across Canada and Australia. This American Life is produced in collaboration with WBEZ Chicago and delivered to stations by PRX The Public Radio Exchange.

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